Whitty A - Search Results

1

Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.

Pepinsky RB, Mumford RA, Chen LL, Leone D, Amo SE, Riper GV, Whitty A, Dolinski B, Lobb RR, Dean DC, Chang LL, Raab CE, Si Q, Hagmann WK, Lingham RB. Pepinsky RB, et al. Among authors: whitty a. Biochemistry. 2002 Jun 4;41(22):7125-41. doi: 10.1021/bi020024d. Biochemistry. 2002. PMID: 12033947

2

A direct binding assay for the vascular cell adhesion molecule-1 (VCAM1) interaction with alpha 4 integrins.

Lobb RR, Antognetti G, Pepinsky RB, Burkly LC, Leone DR, Whitty A. Lobb RR, et al. Among authors: whitty a. Cell Adhes Commun. 1995 Dec;3(5):385-97. doi: 10.3109/15419069509081293. Cell Adhes Commun. 1995. PMID: 8640376

3

Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand.

Chen LL, Whitty A, Lobb RR, Adams SP, Pepinsky RB. Chen LL, et al. Among authors: whitty a. J Biol Chem. 1999 May 7;274(19):13167-75. doi: 10.1074/jbc.274.19.13167. J Biol Chem. 1999. PMID: 10224072 Free article.

4

Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium.

Chen LL, Whitty A, Scott D, Lee WC, Cornebise M, Adams SP, Petter RC, Lobb RR, Pepinsky RB. Chen LL, et al. Among authors: whitty a. J Biol Chem. 2001 Sep 28;276(39):36520-9. doi: 10.1074/jbc.M106216200. Epub 2001 Jul 25. J Biol Chem. 2001. PMID: 11473127 Free article.

5

Enhanced potency of human Sonic hedgehog by hydrophobic modification.

Taylor FR, Wen D, Garber EA, Carmillo AN, Baker DP, Arduini RM, Williams KP, Weinreb PH, Rayhorn P, Hronowski X, Whitty A, Day ES, Boriack-Sjodin A, Shapiro RI, Galdes A, Pepinsky RB. Taylor FR, et al. Among authors: whitty a. Biochemistry. 2001 Apr 10;40(14):4359-71. doi: 10.1021/bi002487u. Biochemistry. 2001. PMID: 11284692

6

The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor.

Cate RL, di Clemente N, Racine C, Groome NP, Pepinsky RB, Whitty A. Cate RL, et al. Among authors: whitty a. J Biol Chem. 2022 Jan;298(1):101429. doi: 10.1016/j.jbc.2021.101429. Epub 2021 Nov 19. J Biol Chem. 2022. PMID: 34801555 Free PMC article.

7

N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.

Baker DP, Lin EY, Lin K, Pellegrini M, Petter RC, Chen LL, Arduini RM, Brickelmaier M, Wen D, Hess DM, Chen L, Grant D, Whitty A, Gill A, Lindner DJ, Pepinsky RB. Baker DP, et al. Among authors: whitty a. Bioconjug Chem. 2006 Jan-Feb;17(1):179-88. doi: 10.1021/bc050237q. Bioconjug Chem. 2006. PMID: 16417267

8

Effect of divalent cations on the affinity and selectivity of alpha4 integrins towards the integrin ligands vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1: Ca2+ activation of integrin alpha4beta1 confers a distinct ligand specificity.

Day ES, Osborn L, Whitty A. Day ES, et al. Among authors: whitty a. Cell Commun Adhes. 2002 Jul-Aug;9(4):205-19. doi: 10.1080/15419060216014. Cell Commun Adhes. 2002. PMID: 12699089

9

Binding efficiency of protein-protein complexes.

Day ES, Cote SM, Whitty A. Day ES, et al. Among authors: whitty a. Biochemistry. 2012 Nov 13;51(45):9124-36. doi: 10.1021/bi301039t. Epub 2012 Nov 1. Biochemistry. 2012. PMID: 23088250 Free PMC article.

10

Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activity.

Runkel L, deDios C, Karpusas M, Betzenhauser M, Muldowney C, Zafari M, Benjamin CD, Miller S, Hochman PS, Whitty A. Runkel L, et al. Among authors: whitty a. Biochemistry. 2000 Mar 14;39(10):2538-51. doi: 10.1021/bi991631c. Biochemistry. 2000. PMID: 10704203

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