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Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in Trichomonas vaginalis.
Miyamoto Y, Aggarwal S, Celaje JJA, Ihara S, Ang J, Eremin DB, Land KM, Wrischnik LA, Zhang L, Fokin VV, Eckmann L. Miyamoto Y, et al. Among authors: wrischnik la. J Med Chem. 2021 May 27;64(10):6608-6620. doi: 10.1021/acs.jmedchem.0c01926. Epub 2021 May 11. J Med Chem. 2021. PMID: 33974434 Free PMC article.
Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo.
Hopper M, Yun JF, Zhou B, Le C, Kehoe K, Le R, Hill R, Jongeward G, Debnath A, Zhang L, Miyamoto Y, Eckmann L, Land KM, Wrischnik LA. Hopper M, et al. Among authors: wrischnik la. Int J Antimicrob Agents. 2016 Dec;48(6):690-694. doi: 10.1016/j.ijantimicag.2016.09.020. Epub 2016 Nov 2. Int J Antimicrob Agents. 2016. PMID: 27839893 Free PMC article.
18 results