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Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts.
Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S, Alitalo K, Lemström KB. Nykänen AI, et al. Among authors: wu y. Circulation. 2010 Mar 30;121(12):1413-22. doi: 10.1161/CIRCULATIONAHA.109.910703. Epub 2010 Mar 15. Circulation. 2010. PMID: 20231530
VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts.
Raisky O, Nykänen AI, Krebs R, Hollmén M, Keränen MA, Tikkanen JM, Sihvola R, Alhonen L, Salven P, Wu Y, Hicklin DJ, Alitalo K, Koskinen PK, Lemström KB. Raisky O, et al. Among authors: wu y. Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):819-25. doi: 10.1161/01.ATV.0000260001.55955.6c. Epub 2007 Feb 8. Arterioscler Thromb Vasc Biol. 2007. PMID: 17290032
Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells.
Vincent L, Jin DK, Karajannis MA, Shido K, Hooper AT, Rashbaum WK, Pytowski B, Wu Y, Hicklin DJ, Zhu Z, Bohlen P, Niesvizky R, Rafii S. Vincent L, et al. Among authors: wu y. Cancer Res. 2005 Apr 15;65(8):3185-92. doi: 10.1158/0008-5472.CAN-04-3598. Cancer Res. 2005. PMID: 15833849
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells.
Hooper AT, Butler JM, Nolan DJ, Kranz A, Iida K, Kobayashi M, Kopp HG, Shido K, Petit I, Yanger K, James D, Witte L, Zhu Z, Wu Y, Pytowski B, Rosenwaks Z, Mittal V, Sato TN, Rafii S. Hooper AT, et al. Among authors: wu y. Cell Stem Cell. 2009 Mar 6;4(3):263-74. doi: 10.1016/j.stem.2009.01.006. Cell Stem Cell. 2009. PMID: 19265665 Free PMC article.
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