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Glucagon receptor antagonism induces increased cholesterol absorption.
Guan HP, Yang X, Lu K, Wang SP, Castro-Perez JM, Previs S, Wright M, Shah V, Herath K, Xie D, Szeto D, Forrest G, Xiao JC, Palyha O, Sun LP, Andryuk PJ, Engel SS, Xiong Y, Lin S, Kelley DE, Erion MD, Davis HR, Wang L. Guan HP, et al. Among authors: xie d. J Lipid Res. 2015 Nov;56(11):2183-95. doi: 10.1194/jlr.M060897. Epub 2015 Sep 15. J Lipid Res. 2015. PMID: 26373568 Free PMC article.
Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.
Roddy TP, McLaren DG, Chen Y, Xie D, Dunn K, Kulick A, Szeto D, Forrest G, Albanese K, Donnelly M, Gai C, Gewain A, Lederman H, Jensen KK, Ai X, Vachal P, Akinsanya KO, Cleary MA, Previs SF, Dansky HM, Johns DG. Roddy TP, et al. Among authors: xie d. Eur J Pharmacol. 2014 Oct 5;740:410-6. doi: 10.1016/j.ejphar.2014.04.015. Epub 2014 Apr 21. Eur J Pharmacol. 2014. PMID: 24769414
AAV8-mediated long-term expression of human LCAT significantly improves lipid profiles in hCETP;Ldlr(+/-) mice.
Chen Z, Chu D, Castro-Perez JM, Ni W, Zhang A, Krsmanovic ML, Xie D, Shah V, Stout SJ, McLaren DG, Stefanni AC, Lee SH, Roddy TP, Plump AS, Hubbard BK, Vogt TF, Zhou HH. Chen Z, et al. Among authors: xie d. J Cardiovasc Transl Res. 2011 Dec;4(6):801-10. doi: 10.1007/s12265-011-9309-8. Epub 2011 Aug 6. J Cardiovasc Transl Res. 2011. PMID: 21822774
Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity.
Haeusler RA, Camastra S, Nannipieri M, Astiarraga B, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Ferrannini E. Haeusler RA, et al. Among authors: xie d. J Clin Endocrinol Metab. 2016 May;101(5):1935-44. doi: 10.1210/jc.2015-2583. Epub 2015 Dec 18. J Clin Endocrinol Metab. 2016. PMID: 26684275 Free PMC article.
Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.
Shang J, Previs SF, Conarello S, Chng K, Zhu Y, Souza SC, Staup M, Chen Y, Xie D, Zycband E, Schlessinger K, Johnson VP, Arreaza G, Liu F, Levitan D, Wang L, van Heek M, Erion M, Wang Y, Kelley DE. Shang J, et al. Among authors: xie d. Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E235-E243. doi: 10.1152/ajpendo.00398.2016. Epub 2017 Jan 31. Am J Physiol Endocrinol Metab. 2017. PMID: 28143858 Free article.
A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects.
Qureshi SA, Rios Candelore M, Xie D, Yang X, Tota LM, Ding VD, Li Z, Bansal A, Miller C, Cohen SM, Jiang G, Brady E, Saperstein R, Duffy JL, Tata JR, Chapman KT, Moller DE, Zhang BB. Qureshi SA, et al. Among authors: xie d. Diabetes. 2004 Dec;53(12):3267-73. doi: 10.2337/diabetes.53.12.3267. Diabetes. 2004. PMID: 15561959
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor.
Duffy JL, Kirk BA, Konteatis Z, Campbell EL, Liang R, Brady EJ, Candelore MR, Ding VD, Jiang G, Liu F, Qureshi SA, Saperstein R, Szalkowski D, Tong S, Tota LM, Xie D, Yang X, Zafian P, Zheng S, Chapman KT, Zhang BB, Tata JR. Duffy JL, et al. Among authors: xie d. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1401-5. doi: 10.1016/j.bmcl.2005.01.003. Bioorg Med Chem Lett. 2005. PMID: 15713396
5,099 results