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Analysis of genetic and clinical factors associated with buprenorphine response.
Crist RC, Vickers-Smith R, Kember RL, Rentsch CT, Xu H, Edelman EJ, Hartwell EE, Kampman KM, Kranzler HR. Crist RC, et al. Among authors: xu h. Drug Alcohol Depend. 2021 Oct 1;227:109013. doi: 10.1016/j.drugalcdep.2021.109013. Epub 2021 Aug 28. Drug Alcohol Depend. 2021. PMID: 34488071 Free PMC article.
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.
Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC, Rentsch CT; Million Veteran Program; Davis LK, Justice AC, Sanchez-Roige S, Kampman KM, Gelernter J, Kranzler HR. Kember RL, et al. Among authors: xu h. Nat Neurosci. 2022 Oct;25(10):1279-1287. doi: 10.1038/s41593-022-01160-z. Epub 2022 Sep 28. Nat Neurosci. 2022. PMID: 36171425 Free PMC article.
Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals.
Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A; Million Veteran Program; Justice AC, Stein MB, Kranzler HR, Gelernter J. Zhou H, et al. Among authors: xu k, xu h, xu j. medRxiv [Preprint]. 2023 Jan 30:2023.01.24.23284960. doi: 10.1101/2023.01.24.23284960. medRxiv. 2023. PMID: 36747741 Free PMC article. Updated. Preprint.
The genetic architecture of pain intensity in a sample of 598,339 U.S. veterans.
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Venegas MP, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT; Million Veteran Program; Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. Toikumo S, et al. Among authors: xu k, xu h. medRxiv [Preprint]. 2023 Mar 13:2023.03.09.23286958. doi: 10.1101/2023.03.09.23286958. medRxiv. 2023. PMID: 36993749 Free PMC article. Preprint.
Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik V, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M; Penn Medicine BioBank, Million Veteran Program, PsycheMERGE Substance Use Disorder Workgroup; Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Toikumo S, et al. Among authors: xu k, xu h. medRxiv [Preprint]. 2023 Sep 18:2023.03.27.23287713. doi: 10.1101/2023.03.27.23287713. medRxiv. 2023. PMID: 37034728 Free PMC article. Preprint.
Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.
Kember RL, Vickers-Smith R, Zhou H, Xu H, Jennings M, Dao C, Davis L, Sanchez-Roige S, Justice AC, Gelernter J, Vujkovic M, Kranzler HR. Kember RL, et al. Among authors: xu h. Am J Psychiatry. 2023 Aug 1;180(8):584-593. doi: 10.1176/appi.ajp.21090892. Epub 2023 Jun 7. Am J Psychiatry. 2023. PMID: 37282553 Free PMC article.
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