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Design, synthesis, and biological evaluation of new-generation taxoids.
Ojima I, Chen J, Sun L, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallager D, Zhao X, Zanardi I, Xia S, Horwitz SB, Mallen-St Clair J, Guerriero JL, Bar-Sagi D, Veith JM, Pera P, Bernacki RJ. Ojima I, et al. Among authors: zanardi i. J Med Chem. 2008 Jun 12;51(11):3203-21. doi: 10.1021/jm800086e. Epub 2008 May 9. J Med Chem. 2008. PMID: 18465846 Free PMC article.
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Matesanz R, Trigili C, Rodríguez-Salarichs J, Zanardi I, Pera B, Nogales A, Fang WS, Jímenez-Barbero J, Canales A, Barasoain I, Ojima I, Díaz JF. Matesanz R, et al. Among authors: zanardi i. Bioorg Med Chem. 2014 Sep 15;22(18):5078-90. doi: 10.1016/j.bmc.2014.05.048. Epub 2014 Jun 19. Bioorg Med Chem. 2014. PMID: 25047938 Free article.
Second-generation taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes.
Otová B, Ojima I, Václavíková R, Hrdý J, Ehrlichová M, Souček P, Vobořilová J, Němcová V, Zanardi I, Horský S, Kovář J, Gut I. Otová B, et al. Among authors: zanardi i. Invest New Drugs. 2012 Jun;30(3):991-1002. doi: 10.1007/s10637-011-9654-0. Epub 2011 Mar 30. Invest New Drugs. 2012. PMID: 21448670
Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.
Jelínek M, Balušíková K, Kopperová D, Nĕmcová-Fürstová V, Šrámek J, Fidlerová J, Zanardi I, Ojima I, Kovář J. Jelínek M, et al. Among authors: zanardi i. Cancer Cell Int. 2013 May 15;13(1):42. doi: 10.1186/1475-2867-13-42. Cancer Cell Int. 2013. PMID: 23672670 Free PMC article.
65 results