Zang Y - Search Results

1

Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.

Liu W, Hussain Z, Zang Y, Sweis RF, Romero FA, Finke PE, Moningka R, Bao J, Plotkin MA, Shang J, Dingley KH, Salituro G, Murphy BA, Howard AD, Ujjainwalla F, Wood HB, Duffy JL. Liu W, et al. Among authors: zang y. ACS Med Chem Lett. 2018 Oct 5;9(11):1088-1093. doi: 10.1021/acsmedchemlett.8b00306. eCollection 2018 Nov 8. ACS Med Chem Lett. 2018. PMID: 30429950 Free PMC article.

2

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, Buist N, Terebetski J, Kelly T, Bugianesi R, Priest BT, Dingley KH, Li X, Mitelman S, Salituro G, Trujillo ME, Pachanski M, Kirkland M, Powles MA, Eiermann GJ, Feng Y, Shang J, Howard AD, Ujjainwalla F, Sinz CJ, Debenham JS, Edmondson SD, Nargund RP, Hagmann WK, Li D. Guo L, et al. Among authors: zang y. ACS Med Chem Lett. 2016 Oct 12;7(12):1107-1111. doi: 10.1021/acsmedchemlett.6b00314. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994747 Free PMC article.

3

Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.

Hussain Z, Cooke AJ, Neelamkavil S, Brown L, Carswell E, Geissler WM, Guo Z, Hawes B, Kelly TM, Kiyoi Y, Lai K, Lesburg C, Pow E, Zang Y, Wood HB, Edmondson SD, Liu W. Hussain Z, et al. Among authors: zang y. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127072. doi: 10.1016/j.bmcl.2020.127072. Epub 2020 Feb 29. Bioorg Med Chem Lett. 2020. PMID: 32340773

4

Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis.

Li J, Liu M, Li Y, Sun DD, Shu Z, Tan Q, Guo S, Xie R, Gao L, Ru H, Zang Y, Liu H, Li J, Zhou Y. Li J, et al. Among authors: zang y. J Med Chem. 2020 Nov 12;63(21):12748-12772. doi: 10.1021/acs.jmedchem.0c01065. Epub 2020 Oct 13. J Med Chem. 2020. PMID: 32991173

5

Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease.

Li Y, Xu T, Zhao Y, Zhang H, Liu Z, Wang H, Huang C, Shu Z, Gao L, Xie R, Jiao T, Zhang D, Zhang D, Liang X, Zang Y, Sun Y, Liu H, Li J, Zhou Y. Li Y, et al. Among authors: zang y. J Med Chem. 2024 Apr 11;67(7):5642-5661. doi: 10.1021/acs.jmedchem.3c02304. Epub 2024 Mar 28. J Med Chem. 2024. PMID: 38547240

6

Discovery of highly potent SARS-CoV-2 M^pro inhibitors based on benzoisothiazolone scaffold.

Chen W, Feng B, Han S, Wang P, Chen W, Zang Y, Li J, Hu Y. Chen W, et al. Among authors: zang y. Bioorg Med Chem Lett. 2022 Feb 15;58:128526. doi: 10.1016/j.bmcl.2022.128526. Epub 2022 Jan 5. Bioorg Med Chem Lett. 2022. PMID: 34998903 Free PMC article.

7

Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.

Zhang X, Kong Y, Zhang J, Su M, Zhou Y, Zang Y, Li J, Chen Y, Fang Y, Zhang X, Lu W. Zhang X, et al. Among authors: zang y. Eur J Med Chem. 2015 May 5;95:127-35. doi: 10.1016/j.ejmech.2015.03.035. Epub 2015 Mar 18. Eur J Med Chem. 2015. PMID: 25805446

8

Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface.

Ren J, Xu W, Tang L, Su M, Chen D, Chen YL, Zang Y, Li J, Shen J, Zhou Y, Xiong B. Ren J, et al. Among authors: zang y. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-4476. doi: 10.1016/j.bmcl.2016.07.074. Epub 2016 Aug 2. Bioorg Med Chem Lett. 2016. PMID: 27528435

9

Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.

Wang J, Su M, Li T, Gao A, Yang W, Sheng L, Zang Y, Li J, Liu H. Wang J, et al. Among authors: zang y. Eur J Med Chem. 2017 Mar 10;128:293-299. doi: 10.1016/j.ejmech.2017.01.035. Epub 2017 Jan 23. Eur J Med Chem. 2017. PMID: 28213282

10

Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.

Yang W, Li L, Ji X, Wu X, Su M, Sheng L, Zang Y, Li J, Liu H. Yang W, et al. Among authors: zang y. Bioorg Med Chem. 2014 Nov 1;22(21):6146-55. doi: 10.1016/j.bmc.2014.08.030. Epub 2014 Sep 4. Bioorg Med Chem. 2014. PMID: 25261927

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