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Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance.
Conarello SL, Li Z, Ronan J, Roy RS, Zhu L, Jiang G, Liu F, Woods J, Zycband E, Moller DE, Thornberry NA, Zhang BB. Conarello SL, et al. Among authors: zhang bb. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6825-30. doi: 10.1073/pnas.0631828100. Epub 2003 May 14. Proc Natl Acad Sci U S A. 2003. PMID: 12748388 Free PMC article.
Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
Jiang G, Dallas-Yang Q, Liu F, Moller DE, Zhang BB. Jiang G, et al. Among authors: zhang bb. J Biol Chem. 2003 Jan 3;278(1):180-6. doi: 10.1074/jbc.M205565200. Epub 2002 Oct 29. J Biol Chem. 2003. PMID: 12409308 Free article.
Glucagon and regulation of glucose metabolism.
Jiang G, Zhang BB. Jiang G, et al. Among authors: zhang bb. Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E671-8. doi: 10.1152/ajpendo.00492.2002. Am J Physiol Endocrinol Metab. 2003. PMID: 12626323 Free article. Review.
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He H, Hickey GJ, Kowalchick JE, Leiting B, Lyons K, Marsilio F, McCann ME, Patel RA, Petrov A, Scapin G, Patel SB, Roy RS, Wu JK, Wyvratt MJ, Zhang BB, Zhu L, Thornberry NA, Weber AE. Kim D, et al. Among authors: zhang bb. J Med Chem. 2005 Jan 13;48(1):141-51. doi: 10.1021/jm0493156. J Med Chem. 2005. PMID: 15634008
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
Kim D, Kowalchick JE, Brockunier LL, Parmee ER, Eiermann GJ, Fisher MH, He H, Leiting B, Lyons K, Scapin G, Patel SB, Petrov A, Pryor KD, Roy RS, Wu JK, Zhang X, Wyvratt MJ, Zhang BB, Zhu L, Thornberry NA, Weber AE. Kim D, et al. Among authors: zhang x, zhang bb. J Med Chem. 2008 Feb 14;51(3):589-602. doi: 10.1021/jm070330v. Epub 2008 Jan 18. J Med Chem. 2008. PMID: 18201067
466 results