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Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
Zhang W, Chan RJ, Chen H, Yang Z, He Y, Zhang X, Luo Y, Yin F, Moh A, Miller LC, Payne RM, Zhang ZY, Fu XY, Shou W. Zhang W, et al. Among authors: zhang zy, zhang x. J Biol Chem. 2009 Aug 14;284(33):22353-22363. doi: 10.1074/jbc.M109.020495. Epub 2009 Jun 9. J Biol Chem. 2009. PMID: 19509418 Free PMC article.
Lack of plakoglobin in epidermis leads to keratoderma.
Li D, Zhang W, Liu Y, Haneline LS, Shou W. Li D, et al. Among authors: zhang w. J Biol Chem. 2012 Mar 23;287(13):10435-10443. doi: 10.1074/jbc.M111.299669. Epub 2012 Feb 7. J Biol Chem. 2012. PMID: 22315228 Free PMC article.
Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.
Chen H, Zhang W, Sun X, Yoshimoto M, Chen Z, Zhu W, Liu J, Shen Y, Yong W, Li D, Zhang J, Lin Y, Li B, VanDusen NJ, Snider P, Schwartz RJ, Conway SJ, Field LJ, Yoder MC, Firulli AB, Carlesso N, Towbin JA, Shou W. Chen H, et al. Among authors: zhang w, zhang j. Development. 2013 May;140(9):1946-57. doi: 10.1242/dev.089920. Development. 2013. PMID: 23571217 Free PMC article.
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