Zhang Z - Search Results

1

Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil.

Zhang Z, Li Y, Stearns RA, Ortiz De Montellano PR, Baillie TA, Tang W. Zhang Z, et al. Biochemistry. 2002 Feb 26;41(8):2712-8. doi: 10.1021/bi0119971. Biochemistry. 2002. PMID: 11851418

2

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.

Zhang Z, Chen Q, Li Y, Doss GA, Dean BJ, Ngui JS, Silva Elipe M, Kim S, Wu JY, Dininno F, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Chem Res Toxicol. 2005 Apr;18(4):675-85. doi: 10.1021/tx0496789. Chem Res Toxicol. 2005. PMID: 15833027

3

Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection.

Chen Q, Tan E, Strauss JR, Zhang Z, Fenyk-Melody JE, Booth-Genthe C, Rushmore TH, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: zhang z. J Pharmacol Exp Ther. 2004 Oct;311(1):307-14. doi: 10.1124/jpet.104.069955. Epub 2004 May 26. J Pharmacol Exp Ther. 2004. PMID: 15163679

4

Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.

Doss GA, Miller RR, Zhang Z, Teffera Y, Nargund RP, Palucki B, Park MK, Tang YS, Evans DC, Baillie TA, Stearns RA. Doss GA, et al. Among authors: zhang z. Chem Res Toxicol. 2005 Feb;18(2):271-6. doi: 10.1021/tx049711r. Chem Res Toxicol. 2005. PMID: 15720132

5

In vitro metabolic activation of lumiracoxib in rat and human liver preparations.

Li Y, Slatter JG, Zhang Z, Li Y, Doss GA, Braun MP, Stearns RA, Dean DC, Baillie TA, Tang W. Li Y, et al. Among authors: zhang z. Drug Metab Dispos. 2008 Feb;36(2):469-73. doi: 10.1124/dmd.107.019018. Epub 2007 Nov 12. Drug Metab Dispos. 2008. PMID: 17998295

6

In vitro bioactivation of a selective estrogen receptor modulator (2S,3R)-(+)-3-(3-hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol (I) in liver microsomes: formation of adenine adducts.

Li Y, Doss GA, Li Y, Chen Q, Tang W, Zhang Z. Li Y, et al. Among authors: zhang z. Chem Res Toxicol. 2012 Nov 19;25(11):2368-77. doi: 10.1021/tx3002466. Epub 2012 Oct 9. Chem Res Toxicol. 2012. PMID: 22998117

7

Metabolite identification and profiling in drug design: current practice and future directions.

Zhang Z, Zhu M, Tang W. Zhang Z, et al. Curr Pharm Des. 2009;15(19):2220-35. doi: 10.2174/138161209788682460. Curr Pharm Des. 2009. PMID: 19601824 Review.

8

Drug metabolism in drug discovery and development.

Zhang Z, Tang W. Zhang Z, et al. Acta Pharm Sin B. 2018 Sep;8(5):721-732. doi: 10.1016/j.apsb.2018.04.003. Epub 2018 Apr 12. Acta Pharm Sin B. 2018. PMID: 30245961 Free PMC article. Review.

9

Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis.

Kim S, Wu JY, Zhang Z, Tang W, Doss GA, Dean BJ, Dininno F, Hammond ML. Kim S, et al. Among authors: zhang z. Org Lett. 2005 Feb 3;7(3):411-4. doi: 10.1021/ol047741f. Org Lett. 2005. PMID: 15673252

10

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.

Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML. Blizzard TA, et al. Among authors: zhang z. Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. doi: 10.1016/j.bmcl.2004.10.036. Bioorg Med Chem Lett. 2005. PMID: 15582421

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