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HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.
Ho YK, Zhi H, DeBiaso D, Philip S, Shih HM, Giam CZ. Ho YK, et al. Among authors: zhi h. J Virol. 2012 Sep;86(17):9474-83. doi: 10.1128/JVI.00158-12. Epub 2012 Jun 27. J Virol. 2012. PMID: 22740410 Free PMC article.
We showed recently that hyperactivation of NF-kappaB by Tax triggers a cellular senescence response (H. Zhi et al., PLoS Pathog. 7:e1002025, 2011). Inhibition of NF-kappaB activation by expression of I-kappaBalpha superrepressor or by small hairpin RNA (shRNA)-media …
We showed recently that hyperactivation of NF-kappaB by Tax triggers a cellular senescence response (H. Zhi et al., PLoS Patho …
540 results