HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.
Ho YK, Zhi H, DeBiaso D, Philip S, Shih HM, Giam CZ.
Ho YK, et al. Among authors: zhi h.
J Virol. 2012 Sep;86(17):9474-83. doi: 10.1128/JVI.00158-12. Epub 2012 Jun 27.
J Virol. 2012.
PMID: 22740410
Free PMC article.
We showed recently that hyperactivation of NF-kappaB by Tax triggers a cellular senescence response (H. Zhi et al., PLoS Pathog. 7:e1002025, 2011). Inhibition of NF-kappaB activation by expression of I-kappaBalpha superrepressor or by small hairpin RNA (shRNA)-media …
We showed recently that hyperactivation of NF-kappaB by Tax triggers a cellular senescence response (H. Zhi et al., PLoS Patho …