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TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease.
Ferreira RR, Abreu RDS, Vilar-Pereira G, Degrave W, Meuser-Batista M, Ferreira NVC, da Cruz Moreira O, da Silva Gomes NL, Mello de Souza E, Ramos IP, Bailly S, Feige JJ, Lannes-Vieira J, de Araújo-Jorge TC, Waghabi MC. Ferreira RR, et al. Among authors: de araujo jorge tc. PLoS Negl Trop Dis. 2019 Jul 31;13(7):e0007602. doi: 10.1371/journal.pntd.0007602. eCollection 2019 Jul. PLoS Negl Trop Dis. 2019. PMID: 31365537 Free PMC article.
Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial.
Alvarenga Americano do Brasil PE, Pereira de Souza A, Hasslocher-Moreno AM, Xavier SS, Lambert Passos SR, de Fátima Ramos Moreira M, Santini de Oliveira M, Sperandio da Silva GM, Magalhães Saraiva R, Santos de Aguiar Cardoso C, de Sousa AS, Mediano MF, Bonecini de Almeida Mda G, da Cruz Moreira O, Britto C, de Araújo-Jorge TC. Alvarenga Americano do Brasil PE, et al. Trials. 2014 Oct 6;15:388. doi: 10.1186/1745-6215-15-388. Trials. 2014. PMID: 25284194 Free PMC article. Clinical Trial.
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers.
Marins-Dos-Santos A, Olivieri BP, Ferreira-Reis R, de Meis J, Silva AA, de Araújo-Jorge TC, Lannes-Vieira J, Cotta-de-Almeida V. Marins-Dos-Santos A, et al. Among authors: de araujo jorge tc. PLoS Negl Trop Dis. 2020 Dec 21;14(12):e0008969. doi: 10.1371/journal.pntd.0008969. eCollection 2020 Dec. PLoS Negl Trop Dis. 2020. PMID: 33347472 Free PMC article.
In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance.
Ferreira RR, de Souza EM, Vilar-Pereira G, Degrave WMS, Abreu RDS, Meuser-Batista M, Ferreira NVC, Ledbeter S, Barker RH, Bailly S, Feige JJ, Lannes-Vieira J, de Araújo-Jorge TC, Waghabi MC. Ferreira RR, et al. Among authors: de araujo jorge tc. Front Cell Infect Microbiol. 2022 Nov 30;12:1017040. doi: 10.3389/fcimb.2022.1017040. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36530434 Free PMC article.
27 results