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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE. Deelen J, et al. Among authors: de craen aj, de geus ej. Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6. Aging Cell. 2011. PMID: 21418511 Free PMC article.
Human insulin/IGF-1 and familial longevity at middle age.
Rozing MP, Westendorp RG, Frölich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D; Leiden Longevity Study (LLS) Group. Rozing MP, et al. Among authors: de craen aj. Aging (Albany NY). 2009 Jul 24;1(8):714-22. doi: 10.18632/aging.100071. Aging (Albany NY). 2009. PMID: 20157552 Free PMC article.
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Beekman M, Nederstigt C, Suchiman HE, Kremer D, van der Breggen R, Lakenberg N, Alemayehu WG, de Craen AJ, Westendorp RG, Boomsma DI, de Geus EJ, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE. Beekman M, et al. Among authors: de craen aj, de geus ej. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18046-9. doi: 10.1073/pnas.1003540107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921414 Free PMC article.
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Böhringer S, van den Akker EB, de Craen AJ, Rivadeneira F, Uitterlinden AG, Westendorp RG, Goeman JJ, Slagboom PE, Houwing-Duistermaat JJ, Beekman M. Deelen J, et al. Among authors: de craen aj. Age (Dordr). 2013 Feb;35(1):235-49. doi: 10.1007/s11357-011-9340-3. Epub 2011 Nov 24. Age (Dordr). 2013. PMID: 22113349 Free PMC article.
The number of p16INK4a positive cells in human skin reflects biological age.
Waaijer ME, Parish WE, Strongitharm BH, van Heemst D, Slagboom PE, de Craen AJ, Sedivy JM, Westendorp RG, Gunn DA, Maier AB. Waaijer ME, et al. Among authors: de craen aj. Aging Cell. 2012 Aug;11(4):722-5. doi: 10.1111/j.1474-9726.2012.00837.x. Epub 2012 Jun 11. Aging Cell. 2012. PMID: 22612594 Free PMC article.
Brain tissue volumes in familial longevity: the Leiden Longevity Study.
Altmann-Schneider I, de Craen AJ, Slagboom PE, Westendorp RG, van Buchem MA, Maier AB, van der Grond J. Altmann-Schneider I, et al. Among authors: de craen aj. Aging Cell. 2012 Dec;11(6):933-9. doi: 10.1111/j.1474-9726.2012.00868.x. Epub 2012 Sep 4. Aging Cell. 2012. PMID: 22882385 Free article.
Gene expression analysis of mTOR pathway: association with human longevity.
Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE. Passtoors WM, et al. Among authors: de craen aj. Aging Cell. 2013 Feb;12(1):24-31. doi: 10.1111/acel.12015. Epub 2012 Nov 23. Aging Cell. 2013. PMID: 23061800 Free article.
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.
Beekman M, Blanché H, Perola M, Hervonen A, Bezrukov V, Sikora E, Flachsbart F, Christiansen L, De Craen AJ, Kirkwood TB, Rea IM, Poulain M, Robine JM, Valensin S, Stazi MA, Passarino G, Deiana L, Gonos ES, Paternoster L, Sørensen TI, Tan Q, Helmer Q, van den Akker EB, Deelen J, Martella F, Cordell HJ, Ayers KL, Vaupel JW, Törnwall O, Johnson TE, Schreiber S, Lathrop M, Skytthe A, Westendorp RG, Christensen K, Gampe J, Nebel A, Houwing-Duistermaat JJ, Slagboom PE, Franceschi C; GEHA consortium. Beekman M, et al. Among authors: de craen aj. Aging Cell. 2013 Apr;12(2):184-93. doi: 10.1111/acel.12039. Epub 2013 Feb 6. Aging Cell. 2013. PMID: 23286790 Free PMC article.
464 results