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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, Guo X, Lu Y, Li M, Jensen RA, Hu Y, Huo S, Lohman KK, Zhang W, Cook JP, Prins BP, Flannick J, Grarup N, Trubetskoy VV, Kravic J, Kim YJ, Rybin DV, Yaghootkar H, Müller-Nurasyid M, Meidtner K, Li-Gao R, Varga TV, Marten J, Li J, Smith AV, An P, Ligthart S, Gustafsson S, Malerba G, Demirkan A, Tajes JF, Steinthorsdottir V, Wuttke M, Lecoeur C, Preuss M, Bielak LF, Graff M, Highland HM, Justice AE, Liu DJ, Marouli E, Peloso GM, Warren HR; ExomeBP Consortium; MAGIC Consortium; GIANT Consortium; Afaq S, Afzal S, Ahlqvist E, Almgren P, Amin N, Bang LB, Bertoni AG, Bombieri C, Bork-Jensen J, Brandslund I, Brody JA, Burtt NP, Canouil M, Chen YI, Cho YS, Christensen C, Eastwood SV, Eckardt KU, Fischer K, Gambaro G, Giedraitis V, Grove ML, de Haan HG, Hackinger S, Hai Y, Han S, Tybjærg-Hansen A, Hivert MF, Isomaa B, Jäger S, Jørgensen ME, Jørgensen T, Käräjämäki A, Kim BJ, Kim SS, Koistinen HA, Kovacs P, Kriebel J, Kronenberg F, Läll K, Lange LA, Lee JJ, Lehne B, Li H, Lin KH, Linneberg A, Liu CT, Liu J, Loh M, Mägi R, Mamakou V, McKean-Cowdin R, Nadkarni G, Neville M, Nielsen SF, N… See abstract for full author list ➔ Mahajan A, et al. Among authors: de haan hg, de mutsert r. Nat Genet. 2018 Apr;50(4):559-571. doi: 10.1038/s41588-018-0084-1. Epub 2018 Apr 9. Nat Genet. 2018. PMID: 29632382 Free PMC article.
Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation.
Hillebrand S, de Mutsert R, Christen T, Maan AC, Jukema JW, Lamb HJ, de Roos A, Rosendaal FR, den Heijer M, Swenne CA; NEO Study Group. Hillebrand S, et al. Among authors: de roos a, de mutsert r. Obesity (Silver Spring). 2014 Jun;22(6):1553-9. doi: 10.1002/oby.20709. Epub 2014 Feb 18. Obesity (Silver Spring). 2014. PMID: 24458875 Free article.
Type 2 diabetes is associated with postprandial amino acid measures.
Mook-Kanamori DO, de Mutsert R, Rensen PC, Prehn C, Adamski J, den Heijer M, le Cessie S, Suhre K, Rosendaal FR, van Dijk KW. Mook-Kanamori DO, et al. Among authors: de mutsert r. Arch Biochem Biophys. 2016 Jan 1;589:138-44. doi: 10.1016/j.abb.2015.08.003. Epub 2015 Aug 10. Arch Biochem Biophys. 2016. PMID: 26271442 Clinical Trial.
Association between Hepatic Triglyceride Content and Left Ventricular Diastolic Function in a Population-based Cohort: The Netherlands Epidemiology of Obesity Study.
Widya RL, de Mutsert R, den Heijer M, le Cessie S, Rosendaal FR, Jukema JW, Smit JW, de Roos A, Lamb HJ; NEO Study Group. Widya RL, et al. Among authors: de roos a, de mutsert r. Radiology. 2016 May;279(2):443-50. doi: 10.1148/radiol.2015150035. Epub 2016 Jan 26. Radiology. 2016. PMID: 26812225
Serum CETP concentration is not associated with measures of body fat: The NEO study.
Blauw LL, de Mutsert R, Lamb HJ, de Roos A, Rosendaal FR, Jukema JW, Wang Y, van Dijk KW, Rensen PC. Blauw LL, et al. Among authors: de roos a, de mutsert r. Atherosclerosis. 2016 Mar;246:267-73. doi: 10.1016/j.atherosclerosis.2016.01.031. Epub 2016 Jan 19. Atherosclerosis. 2016. PMID: 26820801 Free article.
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB, Surakka I, Nolte IM, Zhang W, Mbarek H, Li-Gao R, Trompet S, Verweij N, Evangelou E, Lyytikäinen LP, Tayo BO, Deelen J, van der Most PJ, van der Laan SW, Arking DE, Morrison A, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Mychaleckyj JC, Campbell A, Hocking LJ, Padmanabhan S, Brody JA, Rice KM, White CC, Harris T, Isaacs A, Campbell H, Lange LA, Rudan I, Kolcic I, Navarro P, Zemunik T, Salomaa V; LifeLines Cohort Study; Kooner AS, Kooner JS, Lehne B, Scott WR, Tan ST, de Geus EJ, Milaneschi Y, Penninx BW, Willemsen G, de Mutsert R, Ford I, Gansevoort RT, Segura-Lepe MP, Raitakari OT, Viikari JS, Nikus K, Forrester T, McKenzie CA, de Craen AJ, de Ruijter HM; CHARGE Lipids Working Group; Pasterkamp G, Snieder H, Oldehinkel AJ, Slagboom PE, Cooper RS, Kähönen M, Lehtimäki T, Elliott P, van der Harst P, Jukema JW, Mook-Kanamori DO, Boomsma DI, Chambers JC, Swertz M, Ripatti S, Willems van Dijk K, Vitart V, Polasek O, Hayward C, Wilson JG, Wilson JF, Gudnason V, Rich SS, Psaty BM, Borecki IB… See abstract for full author list ➔ van Leeuwen EM, et al. Among authors: de craen aj, de geus ej, de mutsert r, de ruijter hm. J Med Genet. 2016 Jul;53(7):441-9. doi: 10.1136/jmedgenet-2015-103439. Epub 2016 Apr 1. J Med Genet. 2016. PMID: 27036123 Free PMC article.
221 results