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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE. Deelen J, et al. Among authors: van den akker eb, van duijn cm, van heemst d, van der ouderaa fj, van der breggen r. Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6. Aging Cell. 2011. PMID: 21418511 Free PMC article.
Variation in the SHC1 gene and longevity in humans.
Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline Slagboom P, Westendorp RG; 'Long Life' Study Group. Mooijaart SP, et al. Among authors: van heemst d, van gerwen s. Exp Gerontol. 2004 Feb;39(2):263-8. doi: 10.1016/j.exger.2003.10.001. Exp Gerontol. 2004. PMID: 15036421
Reduced insulin/IGF-1 signalling and human longevity.
van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG. van Heemst D, et al. Aging Cell. 2005 Apr;4(2):79-85. doi: 10.1111/j.1474-9728.2005.00148.x. Aging Cell. 2005. PMID: 15771611 Free article.
ApoE plasma levels and risk of cardiovascular mortality in old age.
Mooijaart SP, Berbée JF, van Heemst D, Havekes LM, de Craen AJ, Slagboom PE, Rensen PC, Westendorp RG. Mooijaart SP, et al. Among authors: van heemst d. PLoS Med. 2006 Jun;3(6):e176. doi: 10.1371/journal.pmed.0030176. Epub 2006 May 9. PLoS Med. 2006. PMID: 16671834 Free PMC article.
306 results