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Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Böhringer S, van den Akker EB, de Craen AJ, Rivadeneira F, Uitterlinden AG, Westendorp RG, Goeman JJ, Slagboom PE, Houwing-Duistermaat JJ, Beekman M. Deelen J, et al. Among authors: van den akker eb, van heemst d. Age (Dordr). 2013 Feb;35(1):235-49. doi: 10.1007/s11357-011-9340-3. Epub 2011 Nov 24. Age (Dordr). 2013. PMID: 22113349 Free PMC article.
Variation in the SHC1 gene and longevity in humans.
Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline Slagboom P, Westendorp RG; 'Long Life' Study Group. Mooijaart SP, et al. Among authors: van heemst d, van gerwen s. Exp Gerontol. 2004 Feb;39(2):263-8. doi: 10.1016/j.exger.2003.10.001. Exp Gerontol. 2004. PMID: 15036421
Reduced insulin/IGF-1 signalling and human longevity.
van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG. van Heemst D, et al. Aging Cell. 2005 Apr;4(2):79-85. doi: 10.1111/j.1474-9728.2005.00148.x. Aging Cell. 2005. PMID: 15771611 Free article.
ApoE plasma levels and risk of cardiovascular mortality in old age.
Mooijaart SP, Berbée JF, van Heemst D, Havekes LM, de Craen AJ, Slagboom PE, Rensen PC, Westendorp RG. Mooijaart SP, et al. Among authors: van heemst d. PLoS Med. 2006 Jun;3(6):e176. doi: 10.1371/journal.pmed.0030176. Epub 2006 May 9. PLoS Med. 2006. PMID: 16671834 Free PMC article.
307 results