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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins.
Hill WD, Davies G, van de Lagemaat LN, Christoforou A, Marioni RE, Fernandes CP, Liewald DC, Croning MD, Payton A, Craig LC, Whalley LJ, Horan M, Ollier W, Hansell NK, Wright MJ, Martin NG, Montgomery GW, Steen VM, Le Hellard S, Espeseth T, Lundervold AJ, Reinvang I, Starr JM, Pendleton N, Grant SG, Bates TC, Deary IJ. Hill WD, et al. Among authors: van de lagemaat ln. Transl Psychiatry. 2014 Jan 7;4(1):e341. doi: 10.1038/tp.2013.114. Transl Psychiatry. 2014. PMID: 24399044 Free PMC article.
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.
Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, Moran J, Chambert K, Toncheva D, Georgieva L, Grozeva D, Fjodorova M, Wollerton R, Rees E, Nikolov I, van de Lagemaat LN, Bayés A, Fernandez E, Olason PI, Böttcher Y, Komiyama NH, Collins MO, Choudhary J, Stefansson K, Stefansson H, Grant SG, Purcell S, Sklar P, O'Donovan MC, Owen MJ. Kirov G, et al. Among authors: van de lagemaat ln. Mol Psychiatry. 2012 Feb;17(2):142-53. doi: 10.1038/mp.2011.154. Epub 2011 Nov 15. Mol Psychiatry. 2012. PMID: 22083728 Free PMC article.
Synaptic scaffold evolution generated components of vertebrate cognitive complexity.
Nithianantharajah J, Komiyama NH, McKechanie A, Johnstone M, Blackwood DH, St Clair D, Emes RD, van de Lagemaat LN, Saksida LM, Bussey TJ, Grant SG. Nithianantharajah J, et al. Among authors: van de lagemaat ln. Nat Neurosci. 2013 Jan;16(1):16-24. doi: 10.1038/nn.3276. Epub 2012 Dec 2. Nat Neurosci. 2013. PMID: 23201973 Free PMC article.
Confirmed rare copy number variants implicate novel genes in schizophrenia.
Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MD, Malloy MP, Muir WJ, Pickard BS, Deary IJ, Blackwood DH, Carter NP, Grant SG. Tam GW, et al. Among authors: van de lagemaat ln. Biochem Soc Trans. 2010 Apr;38(2):445-51. doi: 10.1042/BST0380445. Biochem Soc Trans. 2010. PMID: 20298200
Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.
Frank RA, McRae AF, Pocklington AJ, van de Lagemaat LN, Navarro P, Croning MD, Komiyama NH, Bradley SJ, Challiss RA, Armstrong JD, Finn RD, Malloy MP, MacLean AW, Harris SE, Starr JM, Bhaskar SS, Howard EK, Hunt SE, Coffey AJ, Ranganath V, Deloukas P, Rogers J, Muir WJ, Deary IJ, Blackwood DH, Visscher PM, Grant SG. Frank RA, et al. Among authors: van de lagemaat ln. PLoS One. 2011 Apr 29;6(4):e19011. doi: 10.1371/journal.pone.0019011. PLoS One. 2011. PMID: 21559497 Free PMC article.
34 results