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Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles.
Tijms BM, Vromen EM, Mjaavatten O, Holstege H, Reus LM, van der Lee S, Wesenhagen KEJ, Lorenzini L, Vermunt L, Venkatraghavan V, Tesi N, Tomassen J, den Braber A, Goossens J, Vanmechelen E, Barkhof F, Pijnenburg YAL, van der Flier WM, Teunissen CE, Berven FS, Visser PJ. Tijms BM, et al. Nat Aging. 2024 Jan;4(1):33-47. doi: 10.1038/s43587-023-00550-7. Epub 2024 Jan 9. Nat Aging. 2024. PMID: 38195725 Free PMC article.
Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.
Tomassen J, den Braber A, van der Lee SJ, Reus LM, Konijnenberg E, Carter SF, Yaqub M, van Berckel BNM, Collij LE, Boomsma DI, de Geus EJC, Scheltens P, Herholz K, Tijms BM, Visser PJ. Tomassen J, et al. Among authors: van der lee sj. BMC Neurol. 2022 Dec 15;22(1):484. doi: 10.1186/s12883-022-02925-6. BMC Neurol. 2022. PMID: 36522743 Free PMC article.
What does heritability of Alzheimer's disease represent?
Baker E, Leonenko G, Schmidt KM, Hill M, Myers AJ, Shoai M, de Rojas I, Tesi N, Holstege H, van der Flier WM, Pijnenburg YAL, Ruiz A, Hardy J, van der Lee S, Escott-Price V. Baker E, et al. PLoS One. 2023 Apr 28;18(4):e0281440. doi: 10.1371/journal.pone.0281440. eCollection 2023. PLoS One. 2023. PMID: 37115753 Free PMC article.
Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status.
Le Borgne J; EADB, GR@ACE, Degesco, EADI, GERAD, DemGene; Amouyel P, Andreassen O, Frikke-Schmidt R, Hiltunen M, Ingelsson M, Ramirez A, Rossi G, Ruiz A, Sanchez-Juan P, Sims R, Sleegers K, Tsolaki M, van der Lee SJ, Williams J, Lambert JC, Bellenguez C. Le Borgne J, et al. Among authors: van der lee sj. Alzheimers Dement. 2024 Mar;20(3):2282-2284. doi: 10.1002/alz.13550. Epub 2023 Dec 2. Alzheimers Dement. 2024. PMID: 38041824 Free PMC article. No abstract available.
Human whole-exome genotype data for Alzheimer's disease.
Leung YY, Naj AC, Chou YF, Valladares O, Schmidt M, Hamilton-Nelson K, Wheeler N, Lin H, Gangadharan P, Qu L, Clark K, Kuzma AB, Lee WP, Cantwell L, Nicaretta H; Alzheimer’s Disease Sequencing Project; Haines J, Farrer L, Seshadri S, Brkanac Z, Cruchaga C, Pericak-Vance M, Mayeux RP, Bush WS, Destefano A, Martin E, Schellenberg GD, Wang LS. Leung YY, et al. Nat Commun. 2024 Jan 23;15(1):684. doi: 10.1038/s41467-024-44781-7. Nat Commun. 2024. PMID: 38263370 Free PMC article.
Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: a survey study.
Waterink L, Masselink LA, van der Lee SJ, Visser LNC, Cleutjens S, van der Schaar J, van Harten AC, Scheltens P, Sikkes SAM, van der Flier WM, Zwan MD. Waterink L, et al. Among authors: van der lee sj. Alzheimers Res Ther. 2024 Jan 2;16(1):1. doi: 10.1186/s13195-023-01364-w. Alzheimers Res Ther. 2024. PMID: 38167083 Free PMC article.
Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes.
Reus LM, Boltz T, Francia M, Bot M, Ramesh N, Koromina M, Pijnenburg YAL, den Braber A, van der Flier WM, Visser PJ, van der Lee SJ, Tijms BM, Teunissen CE, Loohuis LO, Ophoff RA. Reus LM, et al. Among authors: van der lee sj. bioRxiv [Preprint]. 2023 Sep 27:2023.09.26.559021. doi: 10.1101/2023.09.26.559021. bioRxiv. 2023. PMID: 37808647 Free PMC article. Preprint.
127 results