microRNAs in aged sperm confer psychiatric symptoms to offspring through causing the dysfunction of estradiol signaling in early embryos

Gaoli Liang; Xiaoju Zhu; Zixuan Zhang; Li Chen; Huijin Feng; Shoubin Zhan; Huanhuan Hu; Ranran Yu; Chen-Yu Zhang; Zhichun Feng; Bing Yao; Yanbo Wang; Xi Chen

doi:10.1038/s41421-022-00414-1

microRNAs in aged sperm confer psychiatric symptoms to offspring through causing the dysfunction of estradiol signaling in early embryos

Cell Discov. 2022 Jul 5;8(1):63. doi: 10.1038/s41421-022-00414-1.

Authors

Gaoli Liang^#¹, Xiaoju Zhu^#¹, Zixuan Zhang^#¹, Li Chen^#², Huijin Feng¹, Shoubin Zhan¹, Huanhuan Hu¹, Ranran Yu¹, Chen-Yu Zhang^{1

3

4}, Zhichun Feng⁵, Bing Yao⁶, Yanbo Wang^{7

8

9}, Xi Chen^{10

11

12

13}

Affiliations

¹ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
² Center of Reproductive Medicine, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu, China.
³ Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
⁴ Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
⁵ Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China. zhichunfeng81@163.com.
⁶ Center of Reproductive Medicine, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu, China. yaobing@nju.edu.cn.
⁷ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. ybwang@nju.edu.cn.
⁸ Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China. ybwang@nju.edu.cn.
⁹ Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu, China. ybwang@nju.edu.cn.
¹⁰ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. xichen@nju.edu.cn.
¹¹ Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China. xichen@nju.edu.cn.
¹² Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China. xichen@nju.edu.cn.
¹³ Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu, China. xichen@nju.edu.cn.

^# Contributed equally.

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