Infectious crystalline keratopathy and endophthalmitis secondary to Mycobacterium abscessus in a monocular patient with Stevens-Johnson syndrome

Am J Ophthalmol. 1999 Feb;127(2):209-10. doi: 10.1016/s0002-9394(98)00354-7.

Abstract

Purpose: To describe the clinical and laboratory features of infectious crystalline keratopathy and endophthalmitis secondary to Mycobacterium abscessus in a patient with Stevens-Johnson syndrome.

Method: Case report. A 19-year-old man with a history of Stevens-Johnson syndrome and multiple corneal transplants developed white crystalline corneal infiltrates.

Results: Anterior chamber aspirate disclosed acid-fast bacilli. A repeat corneal transplant was performed and antibiotic therapy begun. Histopathology showed focal acute inflammation surrounding collections of acid-fast bacilli, which were speciated as M. abscessus.

Conclusions: M. abscessus is a cause of infectious crystalline keratopathy and endophthalmitis. Risk factors include ocular surface disease, corneal transplantation, and immunosuppressive therapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amikacin / therapeutic use
  • Anterior Chamber / microbiology
  • Azithromycin / therapeutic use
  • Corneal Diseases / diagnosis
  • Corneal Diseases / drug therapy
  • Corneal Diseases / microbiology*
  • Drug Therapy, Combination / therapeutic use
  • Endophthalmitis / diagnosis
  • Endophthalmitis / drug therapy
  • Endophthalmitis / microbiology*
  • Eye Infections, Bacterial / diagnosis
  • Eye Infections, Bacterial / drug therapy
  • Eye Infections, Bacterial / microbiology*
  • Humans
  • Keratoplasty, Penetrating
  • Male
  • Mycobacterium / isolation & purification
  • Mycobacterium Infections / diagnosis
  • Mycobacterium Infections / drug therapy
  • Mycobacterium Infections / microbiology*
  • Stevens-Johnson Syndrome / complications*
  • Vision, Monocular*

Substances

  • Azithromycin
  • Amikacin