Our understanding of ocular manifestations in immunological and rheumatological inflammatory disorders has continued to expand over the past year. A report on the characteristics of ocular disease in children with Behçet's disease is presented. Two reports of Vogt-Koyanagi-Harada syndrome in 4-year-old children are discussed, and the uncommon complication of macular edema in this syndrome is highlighted. An article reporting the presence of Epstein-Barr virus DNA in the vitreous of a patient with Vogt-Koyanagi-Harada syndrome is reviewed. Radiologic imaging patterns of orbital disease in Wegener's granulomatosis are presented. Unusual manifestations of sarcoidosis, systemic lupus erythematosus, and Wegener's granulomatosis are also reported.