Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis

Ann N Y Acad Sci. 1999 Jun 30:878:720-3. doi: 10.1111/j.1749-6632.1999.tb07772.x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / physiology*
  • Animals
  • Collagen / biosynthesis*
  • Collagenases / genetics
  • Female
  • Gene Expression Regulation, Enzymologic / drug effects
  • Matrix Metalloproteinase 13
  • Matrix Metalloproteinase 8
  • Matrix Metalloproteinase 9
  • Metalloendopeptidases / biosynthesis
  • Metalloendopeptidases / genetics*
  • Ovariectomy
  • Protease Inhibitors / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Tetracyclines / pharmacology*
  • Wound Healing / drug effects
  • Wound Healing / physiology*
  • Wounds and Injuries / enzymology
  • Wounds and Injuries / physiopathology

Substances

  • Protease Inhibitors
  • Tetracyclines
  • tetracycline CMT-8
  • Collagen
  • Collagenases
  • Matrix Metalloproteinase 13
  • Metalloendopeptidases
  • Mmp13 protein, rat
  • Matrix Metalloproteinase 8
  • Matrix Metalloproteinase 9