HLA-DPB1 alleles in house dust mite allergic patients

Eur J Immunogenet. 1999 Aug;26(4):281-4. doi: 10.1046/j.1365-2370.1999.00151.x.

Abstract

Associations were sought between the presence of allergic sensitivity to Der p 1, a major allergen from the house dust mite, and the HLA-DPB1 genotype. Whilst allergic patients did not differ from controls in DPB1 allelic distribution, there was a correlation of DPB1*11011 with strongly reactive T-cell proliferative responses to Der p 1 and high titre specific IgE to Dermatophagoides pteronyssinus.

MeSH terms

  • Alleles*
  • Allergens / genetics
  • Allergens / immunology
  • Animals
  • Antigens, Dermatophagoides
  • Dust / adverse effects*
  • Genotype
  • Glycoproteins / genetics
  • Glycoproteins / immunology
  • HLA-DP Antigens / genetics*
  • HLA-DP Antigens / immunology
  • HLA-DP beta-Chains
  • HLA-DQ Antigens / genetics
  • HLA-DQ Antigens / immunology
  • HLA-DQ beta-Chains
  • HLA-DR Antigens / genetics
  • HLA-DR Antigens / immunology
  • HLA-DRB1 Chains
  • Humans
  • Hypersensitivity / genetics*
  • Immunophenotyping
  • Mites / immunology*
  • T-Lymphocytes / immunology

Substances

  • Allergens
  • Antigens, Dermatophagoides
  • Dust
  • Glycoproteins
  • HLA-DP Antigens
  • HLA-DP beta-Chains
  • HLA-DPB1 antigen
  • HLA-DQ Antigens
  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains