Melanoma-associated retinopathy and recurrent exudative retinal detachments in a patient with choroidal melanoma

Am J Ophthalmol. 2001 Oct;132(4):578-81. doi: 10.1016/s0002-9394(01)01086-8.

Abstract

Purpose: To report a patient who presented with photopsias, night blindness, exudative retinal detachments, and melanoma-associated retinopathy in her right eye 23 years after the left eye was enucleated for a choroidal melanoma.

Methods: Assessment of fundus findings, fluorescein angiograms, and electroretinograms.

Results: The patient had recurrent exudative detachments of the macula in her right eye and electroretinogram responses consistent with the diagnosis of melanoma-associated retinopathy. The abdominal computed tomography (CT) scan was negative, but 13 months later, CT scanning revealed many masses in her liver. Fine-needle biopsy confirmed the diagnosis of metastatic melanoma.

Conclusion: To our knowledge, this is the first report of melanoma-associated retinopathy in a patient with a previous choroidal melanoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use
  • Choroid Neoplasms / complications*
  • Choroid Neoplasms / drug therapy
  • Choroid Neoplasms / pathology
  • Electroretinography
  • Exudates and Transudates
  • Fatal Outcome
  • Female
  • Fluorescein Angiography
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / etiology
  • Melanoma / complications*
  • Melanoma / drug therapy
  • Melanoma / pathology
  • Paraneoplastic Syndromes / diagnosis
  • Paraneoplastic Syndromes / drug therapy
  • Paraneoplastic Syndromes / etiology*
  • Recurrence
  • Retinal Detachment / diagnosis
  • Retinal Detachment / etiology*
  • Retinal Diseases / diagnosis
  • Retinal Diseases / drug therapy
  • Retinal Diseases / etiology*
  • Tomography, X-Ray Computed
  • Visual Acuity

Substances

  • Antineoplastic Agents