Metastatic adenocarcinoma with rupture through the Bruch membrane simulating a choroidal melanoma

Am J Ophthalmol. 2001 Dec;132(6):943-5. doi: 10.1016/s0002-9394(01)01147-3.

Abstract

Purpose: To report a case of adenocarcinoma metastatic to the choroid with rupture through the Bruch membrane, thus, simulating a choroidal melanoma.

Methods: Interventional case report. Evaluation in a university-based clinic, including a complete eye examination, fluorescein angiography, and ultrasonography; oncological evaluation; and eventual enucleation with histopathological study, including immunohistochemical stains.

Results: A 62-year-old Hispanic female presented with visual loss, right eye, of short duration because of a choroidal mass with retinal detachment. Ultrasonography showed a dome-shaped lesion with an eccentric collar-button projection and medium internal reflectivity, which suggested a choroidal melanoma. Initial systemic evaluation was negative. Severe pain necessitated enucleation, RE, and histopathology of the choroidal mass demonstrated an adenocarcinoma. Further examination revealed a left, upper lobe, nonsmall cell lung carcinoma.

Conclusion: Metastatic choroidal tumors may present, although rarely, with collar-button configurations.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / diagnostic imaging
  • Adenocarcinoma / secondary*
  • Adenocarcinoma / surgery
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers, Tumor / analysis
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / radiotherapy
  • Bruch Membrane / diagnostic imaging
  • Bruch Membrane / pathology*
  • Carcinoma, Non-Small-Cell Lung / diagnosis
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Choroid Neoplasms / diagnostic imaging
  • Choroid Neoplasms / secondary*
  • Choroid Neoplasms / surgery
  • Diagnosis, Differential
  • Eye Enucleation
  • Female
  • Fluorescein Angiography
  • Humans
  • Immunoenzyme Techniques
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / drug therapy
  • Melanoma / diagnosis*
  • Melanoma / diagnostic imaging
  • Melanoma / surgery
  • Middle Aged
  • Pain / diagnosis
  • Retinal Detachment / diagnosis*
  • Retinal Detachment / diagnostic imaging
  • Rupture, Spontaneous
  • Ultrasonography

Substances

  • Biomarkers, Tumor