Liposarcoma metastatic to the orbit

Eur J Ophthalmol. 2003 Jan-Feb;13(1):108-12. doi: 10.1177/112067210301300121.

Abstract

Purpose: To describe a patient with liposarcoma metastatic to the left orbit.

Methods: A 72-year-old man was admitted with diplopia and proptosis of the left eye. Previously, a retroperitoneal liposarcoma had been surgically removed followed by postoperative radiation. Visual acuity was normal. There was proptosis of the left eye, increased retrobulbar resistance and reduced mobility. Trans-septal orbital biopsies showed liposarcoma. The patient was initially treated with prednisolone and later received radio- and chemotherapy. Despite treatment he lost vision of the left eye and died a few months later.

Results: Histological examination of the orbital tumor revealed a spindle-cell liposarcoma similar to the primary tumor of the retroperitoneum.

Conclusions: Liposarcoma metastatic to the orbit is rare, but should be suspected in a patient with proptosis caused by a space-occupying lesion and a history of liposarcoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Combined Modality Therapy
  • Diplopia / etiology
  • Fatal Outcome
  • Humans
  • Ifosfamide / therapeutic use
  • Liposarcoma / diagnostic imaging
  • Liposarcoma / secondary*
  • Liposarcoma / therapy
  • Male
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / secondary*
  • Orbital Neoplasms / therapy
  • Radiotherapy, Adjuvant
  • Retroperitoneal Neoplasms / diagnostic imaging
  • Retroperitoneal Neoplasms / pathology*
  • Tomography, X-Ray Computed
  • Visual Acuity

Substances

  • Antineoplastic Agents, Alkylating
  • Ifosfamide