Contrasting effects of IFNbeta and IVIG in children with central and peripheral demyelination

Neurology. 2003 May 27;60(10):1697-9. doi: 10.1212/01.wnl.0000064163.94122.eb.

Abstract

Reported are three children with MS who responded dramatically to interferon-beta (IFNbeta) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNbeta treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Autoimmune Diseases of the Nervous System / therapy
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Interferon beta-1a
  • Interferon-beta / adverse effects
  • Interferon-beta / therapeutic use*
  • Male
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / therapy*
  • Organ Specificity
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / complications
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / therapy*
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous
  • Interferon-beta
  • Interferon beta-1a