Abstract
The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antibodies, Bacterial / blood
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Antibodies, Bacterial / cerebrospinal fluid*
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Antibody Specificity
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Cerebrospinal Fluid / immunology
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Cerebrospinal Fluid / microbiology
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Child
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Chlamydophila Infections / complications
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Chlamydophila Infections / diagnosis*
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Chlamydophila Infections / immunology*
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Chlamydophila pneumoniae / immunology*
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Chlamydophila pneumoniae / isolation & purification
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Immunoglobulin G / cerebrospinal fluid
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Male
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Multiple Sclerosis / complications*
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Multiple Sclerosis / immunology
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Multiple Sclerosis / microbiology
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Oligoclonal Bands / cerebrospinal fluid
Substances
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Antibodies, Bacterial
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Immunoglobulin G
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Oligoclonal Bands