CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

Koichi Narikawa; Tatsuro Misu; Kazuo Fujihara; Ichiro Nakashima; Shigeru Sato; Yasuto Itoyama

doi:10.1016/j.jneuroim.2003.12.010

CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

J Neuroimmunol. 2004 Apr;149(1-2):182-6. doi: 10.1016/j.jneuroim.2003.12.010.

Authors

Koichi Narikawa¹, Tatsuro Misu, Kazuo Fujihara, Ichiro Nakashima, Shigeru Sato, Yasuto Itoyama

Affiliation

¹ Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan.

PMID: 15020078
DOI: 10.1016/j.jneuroim.2003.12.010

Abstract

The pathogenesis of relapsing neuromyelitis optica (RNMO) remains unknown. We, for the first time, studied the levels of four chemokines in the cerebrospinal fluid in RNMO with ELISA and compared the data with those in multiple sclerosis (MS) and control. CXCL10/IP-10 and CCL17/TARC were significantly elevated in both RNMO and MS. Conversely, CCL2/MCP-1 was significantly lower in MS, but not in RNMO, than in control. CCL11/Eotaxin was not different between groups. None of the four chemokines studied was significantly different between RNMO and MS.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Age of Onset
Chemokines / blood
Chemokines / cerebrospinal fluid*
Enzyme-Linked Immunosorbent Assay / methods
Female
Humans
Male
Multiple Sclerosis / blood
Multiple Sclerosis / cerebrospinal fluid*
Neuromyelitis Optica / blood
Neuromyelitis Optica / cerebrospinal fluid*
Statistics, Nonparametric

Substances

Chemokines