Abstract
The biology of Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia (ALL) is the subject of much interest. We present a case of Ph+ ALL with a minor breakpoint cluster (mBCR) rearrangement who subsequently relapsed with Ph+ mBCR+ acute myeloid leukaemia and later with Ph+ mBCR+ acute stem cell leukaemia. This case provides further evidence that Ph+ ALL with a mBCR rearrangement may arise from a pluripotent stem cell with similar potential to that of chronic granulocytic leukaemia to undergo blastic crises with differing lineage characteristics.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adolescent
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Blast Crisis / pathology
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Female
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Gene Rearrangement / genetics*
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Humans
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Immunophenotyping
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / immunology
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
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Multigene Family / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
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Protein-Tyrosine Kinases*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins c-bcr
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Recurrence
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Stem Cells / immunology
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Stem Cells / pathology
Substances
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Proto-Oncogene Proteins
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Protein-Tyrosine Kinases
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BCR protein, human
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Proto-Oncogene Proteins c-bcr