Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: 2. Second eye involvement and retinal detachment

Ophthalmology. 2004 Dec;111(12):2232-9. doi: 10.1016/j.ophtha.2004.05.028.

Abstract

Purpose: To describe the course of cytomegalovirus (CMV) retinitis in patients with AIDS in the era of highly active antiretroviral therapy (HAART).

Design: Multicenter, prospective, observational study.

Participants: Two hundred seventy-one patients with AIDS and CMV retinitis.

Methods: Follow-up every 3 months with medical history, ophthalmologic examination, laboratory testing, and fundus photographs.

Main outcome measure: Second (contralateral) eye involvement among patients with unilateral disease and retinal detachment (RD).

Results: The overall rate of second eye involvement among patients with unilateral CMV retinitis was 0.07 per person-year (PY); among those with CD4+ T-cell counts of <50/microl it was 0.34/PY, compared with 0.02/PY among those with CD4+ T-cell counts of > or =200/microl (P<0.0001). Risk factors for contralateral eye involvement included low CD4+ T-cell count and detectable CMV load. The overall rate of RD was 0.06/PY; among those with CD4+ T-cell counts of <50/microl it was 0.30/PY, compared with 0.02/PY among those with CD4+ T-cell counts of > or =200/microl (P<0.0001). Risk factors for RD included a low CD4+ T-cell count and larger area of CMV retinitis.

Conclusions: Compared with the rates reported in the pre-HAART era of second eye involvement (approximately 0.40/PY) and RD (approximately 0.50/PY), the rates of these events were reduced among patients in the HAART era. However, among patients with CD4+ T-cell counts of <50/microl, the rates were more similar to those from the pre-HAART era.

Publication types

  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / etiology
  • AIDS-Related Opportunistic Infections / physiopathology*
  • Adult
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active*
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / immunology
  • Cytomegalovirus Retinitis / drug therapy
  • Cytomegalovirus Retinitis / etiology
  • Cytomegalovirus Retinitis / physiopathology*
  • Female
  • Humans
  • Male
  • Prospective Studies
  • Retinal Detachment / drug therapy
  • Retinal Detachment / etiology
  • Retinal Detachment / physiopathology*
  • Risk Factors

Substances

  • Anti-HIV Agents