Abstract
A 62-year-old woman received injections of Restylane, cross-linked hyaluronic acid, for the cosmetic filling of facial rhytids and developed a severe dermal inflammatory reaction. Hyaluronidase administered directly in the inflammatory nodules resulted in rapid resolution of pain, palpable nodularity, and visible induration possibly due to dissolution of the hyaluronic acid.
MeSH terms
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Dermatologic Agents / adverse effects*
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Facial Dermatoses / chemically induced
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Facial Dermatoses / drug therapy*
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Female
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Granuloma, Foreign-Body / chemically induced
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Granuloma, Foreign-Body / drug therapy*
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Humans
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Hyaluronic Acid / adverse effects*
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Hyaluronic Acid / analogs & derivatives*
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Hyaluronoglucosaminidase / administration & dosage
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Hyaluronoglucosaminidase / therapeutic use*
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Injections, Intralesional
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Middle Aged
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Rhytidoplasty*
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Skin Aging
Substances
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Dermatologic Agents
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Hyaluronic Acid
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Hyaluronoglucosaminidase
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Restylane