Diagnosis and management of primary intraocular lymphoma

Grace A Levy-Clarke; Chi-Chao Chan; Robert B Nussenblatt

doi:10.1016/j.hoc.2005.05.011

Diagnosis and management of primary intraocular lymphoma

Hematol Oncol Clin North Am. 2005 Aug;19(4):739-49, viii. doi: 10.1016/j.hoc.2005.05.011.

Authors

Grace A Levy-Clarke¹, Chi-Chao Chan, Robert B Nussenblatt

Affiliation

¹ Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N112, Bethesda, MD 20892, USA. clarkeg@nei.nih.gov

PMID: 16083834
DOI: 10.1016/j.hoc.2005.05.011

Abstract

Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma. The incidence of PIOL has increased in the past 20 years. PIOL often presents as chronic uveitis that is resistant to corticosteroid therapy. Diagnosing PIOL can be challenging and requires an expert pathologist. The treatment of PIOL is difficult because of its high recurrence rate and refractory nature. The objective for the future is to improve diagnostic techniques and therapeutic success while minimizing ocular toxicities.

Publication types

Review

MeSH terms

Central Nervous System Neoplasms* / diagnosis
Central Nervous System Neoplasms* / therapy
Eye Neoplasms* / diagnosis
Eye Neoplasms* / therapy
Humans
Lymphoma* / diagnosis
Lymphoma* / genetics
Lymphoma* / therapy