Transforming growth factor beta(2) increases in subretinal fluid in rhegmatogenous retinal detachment with subretinal strands

Ophthalmologica. 2005 Jul-Aug;219(4):222-5. doi: 10.1159/000085731.

Abstract

Purpose: To compare transforming growth factor (TGF) beta(2) levels in subretinal fluid of rhegmatogenous retinal detachment with or without subretinal strand formation.

Methods: We assessed total and mature TGF-beta(2) levels in subretinal fluid obtained from 24 eyes with rhegmatogenous retinal detachment using an enzyme-linked immunosorbent assay. Group I comprised 18 specimens from eyes without subretinal strands, while group II comprised 6 specimens from eyes with subretinal strands.

Results: Total and mature TGF-beta(2) levels were higher in group II than in group I (p=0.01 and p=0.07, respectively).

Conclusion: The concentrations of total and mature TGF-beta(2) were higher in cases of rhegmatogenous retinal detachment associated with subretinal strand formation compared to those without subretinal strand formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Fluids / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • Exudates and Transudates / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retinal Detachment / metabolism*
  • Transforming Growth Factor beta / metabolism*
  • Transforming Growth Factor beta2

Substances

  • TGFB2 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta2