[Epstein-Barr virus and malignant lymphomas--studies on incidence and localization of viral DNA]

H Herbst; G Niedobitek; I Anagnostopoulos; M Hummel; T Finn; M Bergholz; M Kneba; G Krieger; H Stein

[Epstein-Barr virus and malignant lymphomas--studies on incidence and localization of viral DNA]

Verh Dtsch Ges Pathol. 1990:74:386-9.

[Article in German]

Authors

H Herbst¹, G Niedobitek, I Anagnostopoulos, M Hummel, T Finn, M Bergholz, M Kneba, G Krieger, H Stein

Affiliation

¹ Institut für Pathologie, Klinikum Steglitz, Freie Universität Berlin.

PMID: 1708622

Abstract

Tissue specimens from 198 cases of Hodgkin's disease and 151 non-Hodgkin lymphomas as well as 34 non-malignant lymph node biopsies were examined for the presence of Epstein-Barr virus (EBV) DNA by polymerase chain reaction. EBV-specific DNA sequences were detected in DNA extracts of 58% of Hodgkin's disease biopsies. Non-Hodgkin lymphomas and benign lymph node lesions were associated with EBV in far smaller proportions. In Hodgkin's disease biopsies, subsequent in situ hybridization revealed an exclusive localization of EBV DNA in the tumour cells, suggesting an involvement of EBV in the pathogenesis of Hodgkin's disease in a substantial proportion of cases.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
DNA, Viral / genetics
DNA, Viral / isolation & purification*
Genes, Viral
Herpesvirus 4, Human / genetics
Herpesvirus 4, Human / isolation & purification*
Hodgkin Disease / microbiology*
Hodgkin Disease / pathology
Humans
Lymph Nodes / microbiology*
Lymph Nodes / pathology
Lymphoma, Non-Hodgkin / microbiology*
Lymphoma, Non-Hodgkin / pathology
Molecular Sequence Data

Substances

DNA, Viral