We report on a rare case of a 63-year-old male with malignant fibrous histiocytoma (MFH) metastatic to the right adrenal gland, first diagnosed with fine needle aspiration (FNA) biopsy. The cytological and immunocytochemical study indicated a malignant neoplasm of mesenchymal origin with characteristics of MFH. The patient was then operated on and the pathological and immunohistochemical findings confirmed the cytological diagnosis. FNA becomes more widely useful for the diagnosis of non-palpable masses. It is worth noting that the fluid-based thin-layer "Thin Prep" method provides the possibility to apply immunocytochemical stainings in FNA cytologic material, especially in cases where the material is inadequate.