HLA typing in Vogt-Koyanagi-Harada syndrome in North Indian patients

Ocul Immunol Inflamm. 2007 Mar-Apr;15(2):89-97. doi: 10.1080/09273940601186727.

Abstract

Purpose: To report the HLA profile of VKH patients from India.

Method: Forty-one patients and 50 controls were studied. Phenotyping using a lymphocytotoxicity assay was done for HLA-A and -B. DNA-based sequence-specific low resolution typing was done for HLA-DR and -DQ loci.

Results: HLA-A9 was over-represented in the patient population (p = 0.01), whereas HLA-A11 (p = 0.03) and HLA-DRB1*13 (p = 0.007) were found to be underrepresented. The frequency of HLA-DRB1*04 was 14.6% and 10% in the patient population and controls, respectively. The HLA-DQ frequencies did not differ significantly between patients and controls.

Conclusion: Unlike that reported in most populations, we did not find a significant association between HLA-DRB1*04 and our patient population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • DNA / analysis
  • DNA Fingerprinting
  • Female
  • Follow-Up Studies
  • Gene Frequency
  • HLA-A Antigens / genetics
  • HLA-A Antigens / immunology*
  • HLA-A11 Antigen
  • HLA-DQ Antigens / genetics
  • HLA-DQ Antigens / immunology*
  • HLA-DR Antigens / genetics
  • HLA-DR Antigens / immunology*
  • HLA-DRB1 Chains
  • Histocompatibility Testing*
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Retrospective Studies
  • Seroepidemiologic Studies
  • Uveomeningoencephalitic Syndrome / epidemiology*
  • Uveomeningoencephalitic Syndrome / immunology*

Substances

  • HLA-A Antigens
  • HLA-A11 Antigen
  • HLA-A9 antigen
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • DNA