C-reactive protein levels do not correlate with retinal artery occlusion but with atherosclerosis

Eye (Lond). 2009 Apr;23(4):785-90. doi: 10.1038/eye.2008.159. Epub 2008 Jun 6.

Abstract

Purpose: To determine C-reactive protein (CRP) levels in acute retinal artery occlusion (RAO) and their association with atherosclerotic risk factors.

Methods: CRP levels in 16 patients with RAO were compared with levels in 16 age-matched controls at risk of atherosclerosis and 16 young volunteers. Repeated CRP testing was performed 6 years later.

Results: Elevated CRP levels (>3 mg/l) and risk factors for atherosclerosis were detected in seven patients in the study group (44%) and nine at-risk controls (56%). On follow-up, CRP levels were reduced in all seven retested patients. Six patients died of vascular events within 5 years, of whom four had high CRP levels during RAO.

Conclusions: CRP level correlates with atherosclerosis but it is not significantly elevated in patients with RAO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Atherosclerosis / blood*
  • Atherosclerosis / diagnosis
  • Atherosclerosis / mortality
  • Biomarkers / blood
  • C-Reactive Protein / analysis*
  • Carotid Arteries / diagnostic imaging
  • Case-Control Studies
  • Echocardiography, Doppler
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retinal Artery Occlusion / blood*
  • Risk Factors
  • Young Adult

Substances

  • Biomarkers
  • C-Reactive Protein