Multiple sclerosis on steroids

Matthew S Johnson; Michael S Lee; Brian R Younge; Valerie Purvin

doi:10.1016/j.survophthal.2009.11.002

Multiple sclerosis on steroids

Surv Ophthalmol. 2010 Sep-Oct;55(5):460-6. doi: 10.1016/j.survophthal.2009.11.002. Epub 2010 Mar 29.

Authors

Matthew S Johnson¹, Michael S Lee, Brian R Younge, Valerie Purvin

Affiliation

¹ Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.

PMID: 20347108
DOI: 10.1016/j.survophthal.2009.11.002

Abstract

A 57-year-old man developed acute bilateral vision loss clinically consistent with bilateral optic neuritis. Within 1 month of diagnosis, he developed progressive and severe neurologic dysfunction, and repeat MRI demonstrated enhancement of the optic chiasm and optic tracts, as well as a large enhancing lesion within the right parieto-occipital lobe. Stereotactic-guided brain biopsy demonstrated demyelination consistent with multiple sclerosis. A diagnosis of fulminant multiple sclerosis was made. The patient died within 2 months of diagnosis. Multiple sclerosis and a fulminant subtype known as Marburg disease are discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Blindness / diagnosis
Fatal Outcome
Glucocorticoids / therapeutic use*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / diagnosis*
Multiple Sclerosis / drug therapy
Optic Chiasm / pathology*
Optic Neuritis / diagnosis*
Optic Neuritis / drug therapy
Stereotaxic Techniques
Visual Pathways / pathology

Substances

Glucocorticoids