Cardiopulmonary resuscitation (CPR) in patients with end-stage cancer is an issue of significant clinical and ethical importance. In general, the overall survival to discharge in cancer patients is referred to be 6.2% (localised - 9.5% vs. metastatic disease - 5.6%) compared to 15% of unselected in-hospital arrests. However, immediate survival, as well as survival to discharge after a successful CPR is affected by multiple factors. Type and extend of tumor, degree of clinical deterioration, functional status and many other factors do correlate with outcome in different degrees. Critical illness scoring systems are commonly used in order to assess performance status of patients and predict outcome. This article will review all the above mentioned factors, as well as patients' perception about "do-not-resuscitate" orders and palliative care.