Deep intrastromal bevacizumab injection for management of corneal stromal vascularization after deep anterior lamellar keratoplasty, a novel technique

Cornea. 2011 Feb;30(2):215-8. doi: 10.1097/ICO.0b013e3181e291a6.

Abstract

Purpose: To report the effect of intrastromal injection of bevacizumab in an eye with extensive corneal stromal vascularization after deep anterior lamellar keratoplasty.

Methods: Bevacizumab (2.5 mg/1 mL) was injected into the deep corneal stroma of an eye with severe and extensive stromal vascularization.

Results: Corneal vascularization regressed dramatically after deep stromal injection of bevacizumab with no recurrence after 6 months. Visual acuity was improved, and the patient's complaints subsided.

Conclusions: Corneal intrastromal injection of bevacizumab can be considered for management of intrastromal vascularization after deep anterior lamellar keratoplasty.

Publication types

  • Case Reports

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage*
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Corneal Neovascularization / etiology*
  • Corneal Neovascularization / pathology
  • Corneal Stroma / blood supply*
  • Corneal Transplantation / adverse effects*
  • Corneal Transplantation / methods*
  • Humans
  • Injections, Intraocular
  • Male
  • Treatment Outcome
  • Visual Acuity / drug effects
  • Young Adult

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab