Fatal cerebral phaeohyphomycosis in an immunocompetent individual due to Thielavia subthermophila

Hamid Badali; Jagdish Chander; Ashish Gupta; Hena Rani; Rajpal Singh Punia; G Sybren De Hoog; Jacques F Meis

doi:10.1128/JCM.02648-10

Fatal cerebral phaeohyphomycosis in an immunocompetent individual due to Thielavia subthermophila

J Clin Microbiol. 2011 Jun;49(6):2336-41. doi: 10.1128/JCM.02648-10. Epub 2011 Mar 16.

Authors

Hamid Badali¹, Jagdish Chander, Ashish Gupta, Hena Rani, Rajpal Singh Punia, G Sybren De Hoog, Jacques F Meis

Affiliation

¹ Department of Medical Mycology and Parasitology, School of Medicine/Molecular and Cell Biology Research Centre, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

We report the first case of fatal brain infection in an Indian farmer caused by Thielavia subthermophila, a dematiaceous thermophilic fungus in the order Sordariales, and present a review of previous infections from this order. The patient failed amphotericin B therapy combined with surgical excision despite the drug's low MICs in vitro.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Amphotericin B / administration & dosage
Amphotericin B / pharmacology
Antifungal Agents / administration & dosage
Antifungal Agents / pharmacology
Brain / microbiology
Brain / pathology*
Central Nervous System Fungal Infections / complications
Central Nervous System Fungal Infections / diagnosis*
Central Nervous System Fungal Infections / pathology*
Central Nervous System Fungal Infections / therapy
DNA, Fungal / chemistry
DNA, Fungal / genetics
DNA, Ribosomal Spacer / chemistry
DNA, Ribosomal Spacer / genetics
Debridement
Fatal Outcome
Humans
India
Male
Microbial Sensitivity Tests
Molecular Sequence Data
Phylogeny
Sequence Analysis, DNA
Sordariales / isolation & purification*

Substances

Antifungal Agents
DNA, Fungal
DNA, Ribosomal Spacer
Amphotericin B

Associated data

GENBANK/HM448441
GENBANK/HM448442