Mesangial cells as amyloid factory: a unique contribution of animal models

Kidney Int. 2014 Oct;86(4):669-71. doi: 10.1038/ki.2014.182.

Abstract

AL amyloidosis is a severe complication of plasma-cell disorders, secondary to monoclonal immunoglobulin light chain (LC) deposition in the kidney and other organs. Though the physicochemical properties of amyloid-forming monoclonal LCs have been demonstrated to be involved in their propensity to aggregate, it remains unclear where, when, and finally why amyloid fibrils are formed in vivo. Teng et al. shed light on this long-standing issue thanks to a new animal model.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Amyloid / biosynthesis*
  • Amyloidosis / metabolism*
  • Animals
  • Disease Models, Animal*
  • Glomerular Mesangium / metabolism*
  • Immunoglobulin Light Chains / pharmacology*
  • Kidney Diseases / metabolism*
  • Lysosomes / physiology*
  • Male

Substances

  • Amyloid
  • Immunoglobulin Light Chains