Background: To describe a patient who presented with bilateral serous retinal detachments without the other retinal vascular or ocular inflammatory signs, and who was ultimately diagnosed with acute leukemia.
Methods: Case report and review of the literature.
Results: This patient presented with isolated bilateral serous retinal detachments as the initial manifestation of hematologic malignancy.
Conclusion: Acute leukemia may present with serous retinal detachments without the signs of other retinopathy or ocular inflammation. Incorrect diagnosis may delay detection and proper management of the malignancy. Leukemia should be considered in the differential diagnosis of isolated serous retinal detachments.