Purpose: To report the results of combined photodynamic therapy with verteporfin and intravitreal Avastin delivered on the same day in the treatment of juvenile subfoveal choroidal neovascularization.
Methods: Photodynamic therapy with Visudyne at standard fluence rates and intravitreal Avastin were successfully completed under topical anesthesia in a single day treatment session in an 11-year-old girl with subfoveal choroidal neovascularization.
Patient: A cooperative 11-year-old girl noted sudden vision loss in her right eye with a previous history of a small nonspecific extrafoveal inferior scar, and was noted to have developed an acute subfoveal choroidal neovascular membrane.
Results: The subfoveal choroidal neovascular membrane regressed without any additional therapy or recurrence over an 18-month period and with recovery of 20/20 vision. There were diffuse mild pigmentary changes in the region of the previous choroidal neovascularization.
Conclusion: Choroidal neovascularization in juvenile patients may respond well to a combined photodynamic and intravitreal Avastin therapy delivered in a single day session with excellent recovery of vision and without the need for frequent multiple treatments, which would be difficult in this age group.