Bull'S eye maculopathy in a patient taking sertraline

Retin Cases Brief Rep. 2015 Spring;9(2):131-3. doi: 10.1097/ICB.0000000000000115.

Abstract

Purpose: To report a very rare case of bilateral Bull's eye maculopathy caused by sertraline.

Methods: Clinical case report and literature review.

Patient: A 14-year-old girl.

Results: A 14-year-old girl with no significant medical history developed bilateral Bull's eye maculopathy after taking sertraline for 1 year. Diagnostic work-up, which consisted of electrooculography, electroretinography, and genetic testing, yielded no abnormal results. Three-year follow-up examination after discontinuation of sertraline showed no improvement in visual acuity (20/200 bilaterally) or retinal pigment epithelium. This is the second published case, and according to the National Registry of Drug-Induced Ocular Side Effects, this is only the fifth reported case of presumed sertraline maculopathy.

Conclusion: Although Bull's eye maculopathy related to sertraline is rare, physicians and patients need to be aware of the possible toxicity.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antidepressive Agents / adverse effects
  • Anxiety / drug therapy
  • Diagnosis, Differential
  • Electroretinography
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Macular Degeneration / chemically induced*
  • Macular Degeneration / diagnosis
  • Retinal Pigment Epithelium / pathology*
  • Sertraline / adverse effects*
  • Sertraline / therapeutic use
  • Visual Acuity

Substances

  • Antidepressive Agents
  • Sertraline

Supplementary concepts

  • Macular dystrophy, concentric annular