Detection of Autoantibodies Against Myelin Oligodendrocyte Glycoprotein in Multiple Sclerosis and Related Diseases

Melania Spadaro; Edgar Meinl

doi:10.1007/7651_2015_223

Detection of Autoantibodies Against Myelin Oligodendrocyte Glycoprotein in Multiple Sclerosis and Related Diseases

Methods Mol Biol. 2016:1304:99-104. doi: 10.1007/7651_2015_223.

Authors

Melania Spadaro¹, Edgar Meinl

Affiliation

¹ Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University, Marchioninistr. 15, 81377, Munich, Germany.

PMID: 25814289
DOI: 10.1007/7651_2015_223

Abstract

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with different inflammatory demyelinating diseases of the central nervous system, such as childhood multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), and neuromyelitis optica spectrum disorders (NMOSD). We describe here in detail a sensitive cell-based assay that allows the identification of autoantibodies against MOG in serum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / blood
Autoantibodies / immunology*
Encephalomyelitis, Acute Disseminated / blood
Encephalomyelitis, Acute Disseminated / immunology
Humans
Multiple Sclerosis / blood
Multiple Sclerosis / immunology*
Myelin-Oligodendrocyte Glycoprotein / immunology*
Neuromyelitis Optica / blood
Neuromyelitis Optica / immunology

Substances

Autoantibodies
Myelin-Oligodendrocyte Glycoprotein