A novel MYD88 mutation, L265RPP, in Waldenström macroglobulinemia activates the NF-κB pathway to upregulate Bcl-xL expression and enhances cell survival

Blood Cancer J. 2015 May 15;5(5):e314. doi: 10.1038/bcj.2015.36.

Authors

T Nagao¹, G Oshikawa¹, S Ishida¹, H Akiyama¹, Y Umezawa¹, A Nogami¹, T Kurosu¹, O Miura¹

Affiliation

¹ Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Cell Survival
DNA Mutational Analysis
Gene Expression Regulation, Neoplastic / genetics*
Humans
Immunoblotting
Immunoprecipitation
Male
Middle Aged
Molecular Sequence Data
Mutation*
Myeloid Differentiation Factor 88 / genetics*
Myeloid Differentiation Factor 88 / metabolism
NF-kappa B / metabolism*
Reverse Transcriptase Polymerase Chain Reaction / methods
Signal Transduction* / physiology
Up-Regulation
Waldenstrom Macroglobulinemia / genetics*
Waldenstrom Macroglobulinemia / metabolism
bcl-X Protein / biosynthesis*
bcl-X Protein / genetics

Substances

BCL2L1 protein, human
MYD88 protein, human
Myeloid Differentiation Factor 88
NF-kappa B
bcl-X Protein