Co-infection of invasive pulmonary aspergillosis and cutaneous Fusarium infection in a patient with pyoderma gangrenosum

Nasrin Amirrajab; Masoud Aliyali; Sabah Mayahi; Narges Najafi; Ruhollah Abdi; Omid Nourbakhsh; Tahereh Shokohi

Co-infection of invasive pulmonary aspergillosis and cutaneous Fusarium infection in a patient with pyoderma gangrenosum

J Res Med Sci. 2015 Feb;20(2):199-203.

Authors

Nasrin Amirrajab¹, Masoud Aliyali², Sabah Mayahi³, Narges Najafi⁴, Ruhollah Abdi⁵, Omid Nourbakhsh⁶, Tahereh Shokohi⁷

Affiliations

¹ Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Laboratory Sciences, School of Paramedical Sciences and Tropical Medicine Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Department of Pulmonary Diseases, Mazandaran University of Medical Sciences, Sari, Iran.
³ Department of Medical Mycology and Parasitology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
⁴ Department of Infectious Disease, North Iranian Tropical and Infectious Disease Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
⁵ Department of Radiology, Mazandaran University of Medical Sciences, Sari, Iran.
⁶ Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e Tajrish Hospital, Tehran, Iran.
⁷ Department of Medical Mycology and Parasitology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ; Invasive Fungi Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

PMID: 25983776
PMCID: PMC4400718

Abstract

We report an unusual case of co-infection of invasive pulmonary aspergillosis (IPA) and fusarial skin infection in a patient with classic pyoderma gangrenosum with unknown causes, which were previously controlled with oral prednisolone, cyclosporine. The diagnosis was made on direct microscopy and culture of endobronchial washing, bronchoalveolar lavage and skin lesion biopsy. The treatment failed, and the patient expired 12 days following hospitalization. This report highlights the rarity of coexistence of IPA and a chronic fusarial skin infection and thereby reinforcing the physician's attention toward the possibility of invasive fungal infection in the immunosuppressed patients.

Keywords: Aspergillus; Fusarium; invasive pulmonary aspergillosis; pyoderma gangrenosum.

Publication types

Case Reports